Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. MSDS/SDS Database Search | serum. 5 to 20 times more than for tumor cells. A straight line relationship is obtained, which for our Beckman Model DUUltraviolet Spectro-photometer followed the equation: (density unknown-density blank) X15.8=mg. Int J Cancer. Skip to page content; Skip to site menu on this page. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Il est obtenu à partir de l'extrait de la cannelle, à laquelle son ester éthylique donne son odeur caractéristique, ou de certains arbustes balsamiques. Mise à jour : 1984-01-30. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. The most plant phenolics are derived from trans-cinnamic acid, which is formed from l-phenylalanine by the action of l-phenylalanine ammonia-lyase (PAL), the branch point enzyme between primary (shikimate pathway) and secondary (phenyl propanoid pathway) metabolism (Fig. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. CINNAMIC ACID U14A832J8D Overview Structure Names 25: Classification 2: Identifiers 12: Relationships 4: Metabolites 1: Active Moiety 1: Notes 3: Audit Info References 34: History 1: … CAS Number : 621-82-9 : Molecular Formula : C9H8O2 : Molecular weight : 148.16 : EINECS : 205-398-1 : Melting point : 133 : Boiling Point : 300 : View Complete Details. Molecular Weight 148.16 . EnvironmentalChemistry.com. ethyl 4-imino-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate, 1-phenyl-3,4-dihydro[1]benzothieno[3,2-c]pyridine, 1,2-diphenyl-2-(2-pyridinylamino)ethanone (20622-21-3), methyl 2-[(1Z)-2-nitro-1-propenyl]phenyl ether (6306-34-9), N,N-dimethyl-1-phenyl-1-propanamine (3330-05-0), 6-(4-chlorophenyl)-4,5-dihydro-3(2H)-pyridazinone (1079-73-8), 4,4'-Diaminodicyclohexylmethane (1761-71-3), ethyl 1-ethyl-4-(4-hydroxyphenyl)-2-oxo-3-cyclohexene-1-carboxylate, diethyl 2-bromophenylphosphonate (77526-90-0), bis(4-chlorophenyl)(hydroxy)acetic acid (23851-46-9), Journal of the American Chemical Society, 75, p. 1068, 1953. IndiaMART > Industrial Chemicals & Supplies > Cinnamic Acid. CAS 140-10-3, chemical formula C₆H₅CH=CHCOOH. The cell lines used, established from human malignant tumors, are A549 (lung cancer); PC3(M), Du145, and LNCaP (prostate cancer); A172, U251 (glioblastoma); and SKMEL28, A375(M), 1011 (melanoma). trans-Cinnamic acid is an antimicrobial activity, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. Identification Product Name trans-Cinnamic acid Cat No. cinnamic acid per 100 ml. One such malignancy that still remains a therapeutic challenge mainly due to its heterogeneity and inaccessibility to t … ChemSynthesis Chemical database. : A13538 CAS-No 140-10-3 Synonyms 3-Phenyl-2-propenoic acid; trans-3-Phenylacrylic acid Recommended Use Laboratory chemicals. You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). Cinnamic acid and cinnamyl alcohol showed no irritation potential and no observed effect level (NOEL) for irritation caused by cinnamaldehyde was established at 1.25%. Stable. Liu L, et al. Cinnamic acid. At last,trans-Cinnamic acid… trans-Cinnamic acid; Noms anglais : trans-Cinnamic acid; Utilisation et sources d'émission. Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. Briefly, 5 X104 cells are plated in each well of a 24-well plate, allowed to attach overnight, and treated with compounds (e.g., Cinnamic acid: 2.5, 5, 10, 20, 30 mM) the following day. Molecular Formula: C 9 H 8 O 2; Molecular Weight: 148.161 g/mol; Cas Number: 140-10-3 ; EINECS Number: 205-398-1; MDL Number: MFCD00004369 ; InChIKey: WBYWAXJHAXSJNI … Phenylacrylic acid; 3-Phenylacrylic acid; 3-Phenyl-2-propenoic acid, 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%, 4-09-00-02002 (Beilstein Handbook Reference). Get Latest Price Request a quote. Properties of Cinnamic Acid: Name: Cinnamic Acid: Other Names: Cinnamylic acid, Isocinnamic acid, Benzenepropenoic acid, trans-Cinnamic acid, Phenylacrylic acid, 3-Phenylacrylic acid: Appearance: White monoclinic crystals: Molecular Formula: C 9 H 8 O 2: Melting Point: 133 °C: Boiling Point: 300 °C: Density: 1.2475 g/cm 3: Molar Mass: 148.161 g.mol –1: Solubility in Water Get all suppliers and price by the below link: Reference only. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. Cinnamic acid. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. Molecular Weight: 153.19 g/mol. Fabrication de produits organiques Hygiène et sécurité Apparence . Buying Leads | Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness[1]. This page contains information on the chemical Cinnamic Acid including: 56 synonyms/identifiers. Product Classification | Journals | Cinnamic acid; 2-Propenoic acid, 3-phenyl- (E)-; trans-3-Phenylacrylic acid; trans-beta-Carboxystyrene Chemical Name: trans-Cinnamic Acid Chemical Formula: C9-H8-O2 Contact Information: Sciencelab.com, Inc. 14025 Smith Rd. About Us | A. Viability is determined by Trypan-blue exclusion assay[1]. Biologically Active Compounds | Propriétés physiques . - Find MSDS or SDS, a COA, data sheets and more information. CAS Number: 621-82-9; FEMA Number: 2288; Synonyms/Related: (2E)-3-phenylprop … Solide cristallin, jaunâtre à odeur aromatique. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. cinnamic acid, (E)-Formula: C 9 H 8 O 2: Molar Mass: 148.161: Additional Names: trans-cinnamic acid (E)-cinnamic acid: 2-propenoic acid, 3-phenyl-, (E)-trans-3-phenylacrylic acid : trans-3-phenylpropenoic acid: Please be patient while the web interface loads... Property Availability . trans-cinnamic acid: ChEBI ID CHEBI:35697: ChEBI ASCII Name trans-cinnamic acid: Definition The E (trans) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. 3.3). Articles of Cinnamic acid are included as well. Mise à jour : 1986-11-10. check more Cinnamic acid price, Home | It exists as both a cis and a trans isomer, although the latter is more common. It has a role as a plant metabolite. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. It is a self-inhibitor produced by fungal spores to prevent germination. Create: Cinnamic acid: a natural product with potential use in cancer intervention. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. Date s: Modify: 2020-10-10. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Customer Support; Technical Service; … Cinnamic acid CAS 140-10-3. It is a member of styrenes and a member of cinnamic acids. B. Mise à jour : 1984-01-30. Synonyms: TRANS-CINNAMIC-D5 ACID. It is a self-inhibitor produced by fungal spores to prevent germination. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. Acide cinnamique Cinnamic acid for synthesis. Environmental, Chemistry & Hazardous Materials News, Careers & Resources. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. Rs 850/ Kilogram Get Latest Price. Liu L, et al. Mise à jour : 1986-11-10. Cinnamic acid (CA) and ferulic acid (FA) are naturally occurring phenolic acids claimed to exert beneficial effects against disorders related to oxidative stress, including cancer. Combustible. ACM352431482. Int J Cancer. cinnamic acid. NOEL for sensitization was determined at 2.5% and 0.5% for cinnamyl alcohol and cinnamal, respectively, while cinnamic acid is non‐sensitizing. Fabrication de produits organiques Hygiène et sécurité Apparence . LD The alkali salts are sol in water. Cinnamic acid, ethanol and temperature interaction on coumarate decarboxylase activity and the relative expression of the putative cd gene in D. bruxellensis cis-cinnamic acid: ChEBI ID CHEBI:35699: ChEBI ASCII Name cis-cinnamic acid: Definition The Z (cis) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. The alkali salts are sol in water. Cinnamic acid: a natural product with potential use in cancer intervention. Service & Support. Articles of Cinnamic acid are included as well. Chemical Database Cinnamic Acid Identifications. Details of the supplier of the safety data … Cinnamic acid; Utilisation et sources d'émission. LD 50 (g/kg): 3.57 orally in … It exists as both a cis and a trans isomer, although the latter is more common. Selling Leads | Cinnamic acid - cas 140-10-3, synthesis, structure, density, melting point, boiling point. Houston, Texas 77396 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 Order Online: ScienceLab.com CHEMTREC (24HR Emergency … Propriétés physiques . 1995 Jul 28;62(3):345-50. Hazard Symbols: Xi - Irritant: Risk Codes: R36/37/38 - Irritating to eyes, respiratory system and skin. Il a été découvert et purifié par Péligot et Dumas en 1834. Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. 1995 Jul 28;62(3):345-50. Linear Formula C 6 H 5 CH=CHCOOH . After 3 days of continuous treatment with Cinnamic acid, a dose-dependent loss of invasive capacity in 3 tested tumor lines is observed. Density: 1.185g/cm 3: Melting Point: 131-136℃ Boling Point: 264.999°C at 760 mmHg: Flash Point: 189.53°C: Solubility: 0.4 g/L (20℃) Vapor Presure: 0.005mmHg at 25°C: Refractive Index: 1.616: trans-Cinnamic acid - Risk and Safety. Molecular Formula C 9 H 8 O 2; Average mass 148.159 Da; Monoisotopic mass 148.052429 Da; ChemSpider ID 392447 Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. EC Number 205-398-1. Cells are grown for 3 days at 37°C in the presence or absence of the drug, then detached with trypsin/EDTA and counted in a Coulter counter. Freely sol in benzene, ether, acetone, glacial acetic acid, carbon disulfide, oils. It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. trans-cinnamic acid shows moderate inhibition on the rainbow trout intestinal isolates A. sobria SY-AS3 and S. baltica, SY-S145, gill isolate F. spartansii SY-FS1 and fish pathogens A. salmonicida ATCC 33658, Listonella anguillarum, SY-L24, V. crassostreae SY … PubChem Substance ID … Solide cristallin, jaunâtre à odeur aromatique. Uses advised against Food, drug, pesticide or biocidal product use. SAFETY DATA SHEET Creation Date 26-Sep-2009 Revision Date 14-Feb-2020 Revision Number 2 1. Service | (E)-Cinnamic acid - chemical information, properties, structures, articles, patents and more chemical data. trans-Cinnamic acid ≥99% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. Incompatible with strong oxidizing agents. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Cinnamic acids play key roles in the formation of other more complex phenolic compounds. MDL number MFCD00004369. This factor (15.8) mayvary for different spectrophotom-eters and should be determined individually for any given instrument. Growth rates are determined by cell counting. Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. Cinnamic acid, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200 mg, 1133933: Cinnamic acid, United States Pharmacopeia (USP) Reference Standard, 8.00235: Cinnamic acid, for synthesis, Sorry we cannot compare more than 4 products at a time. Display Name: trans-cinnamic acid EC Number: 205-398-1 EC Name: trans-cinnamic acid CAS Number: 140-10-3 Molecular formula: C9H8O2 IUPAC Name: (2E)-3-phenylprop-2-enoic acid [1]. It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. Home; Text Search; Structure Search ; About; GO. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Contact Seller Ask for best deal. Enterprises. It is found in Cinnamomum cassia. It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. Cinnamic acid (C 9 H 10 O 2-purity 99%) was obtained from Acros Organics (Thermo Fisher Scientific, NJ, USA), diluted in RPMI 1640 medium containing 0.1 g/L of L-glutamine, 2.2 g/L sodium bicarbonate, and 10 mL/L of nonessential amino acids, and supplemented with 10% heat-inactivated fetal calf serum. L'acide cinnamique de formule C 6 H 5 –CH=CHCOOH est un acide organique qui se présente sous la forme d'une poudre blanche inodore, avec une faible solubilité dans l'eau. Beilstein/REAXYS Number 1905952 . A cis and a trans isomer, although the latter is more common a precursor to sweetener. For our Beckman Model DUUltraviolet Spectro-photometer followed the equation: ( density unknown-density blank ).... Cinnamic acid more information is observed IC50 in FS4 cells, i.e, carbon,! 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( density unknown-density blank ) X15.8=mg, vendor, prices, Price, manufacturers of trans-cinnamic acid 140-10-3! Which for our Beckman Model DUUltraviolet Spectro-photometer followed the equation: ( density unknown-density blank X15.8=mg... To phenylalanine production of methyl, ethyl and benzyl esters, which is used in production... 28 ; 62 ( 3 ):345-50, Careers & Resources cause an IC50 in FS4 cells,.. Activity, with minimal inhibitory concentration ( MIC ) of 250 μg/mL against fish pathogen A.,. At the 3-position line relationship is obtained, which is used in flavors, synthetic indigo pharmaceuticals! Acid bearing a phenyl substituent at the 3-position the formula C6H5CH=CHCOOH can browse... Latter is more common glacial acetic acid, it occurs naturally in number! Cells, i.e against fish pathogen A. sobria, SY-AS1 - Irritant: Codes! Suppliers and Price by the below link: Reference only 140-10-3, synthesis, structure density... 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