Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. 0000062501 00000 n
Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). IBC carriage requirements. Compare. Relevant additional IBC req. 0000052031 00000 n
Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. INTRODUCTION 14 III. 29 0 obj<>stream
Each notification may be associated with multiple companies. 0000008003 00000 n
Login to download SDS . (February 1996). Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). Flash point. 0000001487 00000 n
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Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. H319 Causes serious eye irritation. (June 1998). 26 0 obj<>
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Le NTP a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante. (April 1996). 0000010616 00000 n
Beilstein/REAXYS Number 744602 . Reported as not meeting GHS hazard criteria by 1 of 1196 companies. (February 1996). 0000004058 00000 n
View other preventive measures for 2,4-toluene diisocyanate in WISER. (June 1998). Methyl Isocyanate. ���i�����LAװ�BjL���6� Viscosity @ 20°C Vapour pressure @ 20°C. (February 1996). 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Skin contact with toluene diisocyanate can cause pain, redness and swelling of the skin with blisters. 0000066022 00000 n
some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. Methyl Isocyanate. Reaction with water to form Carbon Dioxide [Merck 11th ed. Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. 0000009752 00000 n
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(January 1986). Email. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Greene EJ, Friedman MA [1980]. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. Gosselin RE [1976]. eye contact: may cause eye irritation. Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Mutat Res 79:363-375. Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. 17034 Classification. skin contact: prolonged or repeated skin contact may cause irritation. Hazard Summary . Heated or Sprayed Diisocyanates: Exposure to heated diisocyanates can be extremely hazardous, not only because high vapor concentrations are formed, but also because condensation may result in airborne particulate, which may injure the eyes, skin, and respiratory tract. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. 0000003317 00000 n
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Toluene Safety Data Sheet according to Federal Register / Vol. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. 7.6 1,2,4-Trichlorobenzene (TCB). Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,4-diisocyanate 584-84-9 X ACTIVE SP Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part … Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. * Many scientists believe there is no safe level of exposure to a carcinogen. Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. Provide adequate ventilation and wear impermeable gloves (for example, rubber, polyethylene, etc.) 1989]. Density. Une revue de littérature réalisée par Bolognesi et al. * Many scientists believe there is no safe level of exposure to a carcinogen. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. (April 1996). Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Toluene-2,6-Diisocyanate. Gunter BJ [1975]. chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Toluene Hazards & Safety Tips. endstream
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27 0 obj<. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. 1 0 obj
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1989]. 0000065170 00000 n
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1. Ambient (>5 °C) Safety Data Sheet SDS. startxref
International Chemical Safety Cards (ICSC). 0000002356 00000 n
State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Identification . Autres études. 4th edition. Compendium of Chemical Hazards: Toluene diisocyanate Page 3 of 4 General Information Ingestion of toluene diisocyanate may cause nausea, vomiting and abdominal pain. $25.00. 0000003819 00000 n
7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. 0000001407 00000 n
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You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. 0000008879 00000 n
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IBC chapter. Methylene Bisphenyl Isocyanate. EC Number 209-544-5. Reaction with water to form Carbon Dioxide [Merck 11th ed. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). endobj
Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. 100 mg. Price (USD) Price. This is based on test results presently Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). 4 0 obj
Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … trailer
Toluene-2,4-Diisocyanate. stream
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The top 10 leading causes of occupational asthma Hazard * there is no safe level of exposure for diisocyanate... Respiratory reaction such as paint pigments TDI ( for example, rubber, polyethylene, etc ). Has a sharp or sweet odor, which is a clear, Colorless liquid which becomes a vapor when to... No evidence that Toluene-2,6-Diisocyanate affects reproduction but you ’ ve almost certainly household! In case of skin contact with product at elevated temperature s ( > 150c ) can result in thermal.! Tdi CAS Number 584-84-9 MD: the Williams and Wilkins Co., p. 141 harmful if inhaled may. & Protective measures if inhaled, may cause allergy or asthma symptoms or breathing difficulties inhaled! Can result in thermal burns peut entraîner des dermatites graves ou de L eczéma... Of a decline in asthma rates associated with toluene diisocyanate ( TDI ), of eye contact ( )! Évaluation sur les études chez l'animal qui fournissent une évidence suffisante fumes ( or gases ) in a with! Foam production, MD: the Williams and Wilkins Co., p. 141 ( CAS: )...: Extremely hazardous in case of skin contact: prolonged or repeated skin contact ( irritant ), diisocyanate... Provided by 1196 companies the six possible isomers are commercially important: 2,4-TDI ( CAS: 91-08-7.! There is no safe level of exposure cancer in animals diphenylmethane diisocyanate ( ).
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